Hi Tracy,
Looks like you've had some good replies below.
With using dexmedetomidine, it is important that it is given by a route where it isn't swallowed. Once swallowed, it's almost completely broken down by first pass metabolism. Rather than mixing it in with food, you can try to administer the liquid into the mouth so it is absorbed OTM. Just prior to Sileo coming on to the market in the US, a criticalist colleague of mine and I published a short case series using this method in the Canadian Vet Journal in 2015. Not the most reliable results, and remember this was a case series, so not all cases followed the exact same plan.
Clinically, I would say that if you can keep the environment around the dog quiet and calm, I'm thinking covered cage fronts and keep other barking dogs quiet or away, any of the protocols below are destined to work better.
I found that the dexmedetomidine mixed with morphine was by far the most effective in our case series. Though not the most sophisticated administration, we squirted it into the dog's mouth via a syringe with a 22 to 18 gauge needle from a distance of ~ 3 feet for those dogs we couldn't get anywhere near. That allowed orotransmucosal contact and absorption.
Also, if you're willing to try oral meds ahead of time, we've also given large doses of trazodone in a cheeseburger the morning of (for later day euth) or the night before (for first thing in the am euth) and then use any of the injectables mentioned or OTM route just prior. I find I need to give a dose of at least 8 mg/kg of trazodone a good couple of hours for those dogs that won't let me anywhere near them. They're still not your fans, but generally I can get close enough to safely give an IM injection in the rear.
Play around with the protocols mentioned, and see what works best for you.
I will also say, that anything you can do during their bite hold to reduce stress can help to prevent them from getting this reactive by the end of it. Even doing a quiet kennel exercise (everyone tosses treats as they pass by), keeping noise lower, and managing visual triggers can help to prevent this.
I recently did an audio recording about noise in shelters and was absolutely floored by the amount of noise in shelters that is human made just by lack of awareness. Think about how you shut the door, put the bowls down, move the mop bucket, etc.
Hope this helps a little,
Sara
#Medicine,SurgeryandSterilization