Thanks to everyone for joining us at today's panel and thanks for Maddie's Fund for hosting us!
I wanted to share a bit about post-CPMA use and vaccination protocols because CPMA can interfere with parvo vaccination:
CPMA is great for treating and preventing parvo, but it can get in the way of parvo vaccination for a while because the CPMA's passive antibodies can "soak up" the vaccine and blunt its response. The manufacturer's (Elanco) message is: assume CPMA can interfere with vaccines for several weeks and plan to extend a final DHPP shot so the puppy eventually mounts its own strong, lasting immunity.
So what this means in practice:
For puppies that were sick with parvo and treated with CPMA, continue or restart MLV DHPP as soon as they are clinically stable and out of isolation, using your usual post‑parvo vaccination protocol. The main goal here is distemper and other core pathogen coverage, because while recovery from natural parvo infection is expected to give them lifelong parvo immunity, does nothing for distemper.
Because CPMA protects against parvo for a period of time but also blocks the parvo component of the DHPP vaccine from working for several weeks, the manufacturer recommends giving a final parvo shot (as an MLV DHPP shot) at least 17 weeks AFTER the CPMA injection so the drug has cleared and the puppy can ensure it builds active immunity. Again, this type of pup that was truly infected w/ parvo will likely have lasting immunity to parvo but this final DHPP shot is just to be extra safe.
If CPMA is used as prophylaxis in an exposed but not yet sick puppy, both maternally derived antibodies (MDA) and CPMA may interfere with vaccination for even longer. To be conservative, you can plan one "insurance" MLV DHPP dose about 24 weeks AFTER the CPMA dose so you are confident that both MDA and CPMA are out of the way and the vaccine can take.
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Chumkee Aziz, DVM, DABVP (Shelter Medicine Practice)
Outreach Veterinarian
UC Davis
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